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Yes — not feeling the desire to do anything can be a sign of depression, particularly when it means losing interest or pleasure in things the person normally enjoys. This is often called anhedonia, and it’s one of the core symptoms of depression.
But it doesn't automatically mean depression. People can feel this way because of stress, burnout, grief, poor sleep, illness, medication effects, or other mental-health issues.
A few things make it more concerning:
It’s been happening most days for 2+ weeks.
Things they normally enjoy don't feel enjoyable anymore.
They're unusually tired, withdrawn, hopeless, irritable, or having trouble concentrating.
Sleep or appetite has changed.
It's interfering with work, relationships, hygiene, or everyday responsibilities.
And importantly, someone doesn't have to feel sad to be depressed. Sometimes the dominant feeling is simply “I don't care about anything” or “I don't want to do anything.”
If this has been going on for a while, encouraging your friend to talk with a doctor or mental-health professional would be reasonable. Medical conditions and some medications can produce symptoms that resemble depression, so it's worth getting assessed rather than trying to diagnose it themselves.
If you want, you can tell me what “not feeling the desire to do anything” looks like for your friend and how long it's been going on, and I can help you gauge whether it sounds more like depression, burnout, or something else.