>>3958810shits easy actually,with a few exploits of course,luck 9 int 9 agility 8 (since it gives 9 points which is fine because starting fo3 unarmed is 3 points which is 3 hits)
Tag skills gambling unarmed speech
Go to the junktown,use a autoclicker casino exploit and get filthy rich
then to the boneyard,go through the deathclaws into the gun runners shop,get the combat armor and power fist,with a few energy cells for backup,then radaway and radx,into the glowing,clear out all the levels since combat armor provides plenty of defense against the robots there,get into the bos bunker show the tapes,get power armor (through sneaking into the room getting the part for it and repairing it)
then in boneyard help some dude with his quest,get the chemical notebook and now you have hardened power armor,the strongest in the game,now put 150% in unarmed and the rest of the game is a cakewalk